@article{Ramadhan_Zahra_Rampengan_Reviano_Yasin_Jayanthi_Raditya_Saputra_Ega_Ariyanto_et al._2026, place={Fidenza, Italy}, title={Efficacy and safety of novel beta-lactam/beta-lactamase inhibitor combinations in multidrug-resistant gram-negative bacterial infections: A systematic review and meta-analysis}, volume={97}, url={https://mattioli1885journals.com/index.php/actabiomedica/article/view/18826}, DOI={10.23750/abm.2026.18826}, abstractNote={
Background and aim: Multidrug-resistant Gram-negative bacterial infections (MDR-GNB) pose a significant global health challenge, limiting the effectivity of standard antibiotics treatment and contributing to increased morbidity and mortality. Beta-lactam/beta-lactamase inhibitor (BL/BLI) combinations have emerged as promising alternatives to standard antibiotic therapy. This systematic review and meta-analysis aim to evaluate the efficacy and safety of BL/BLI combinations in MDR-GNB infections. Methods: A comprehensive literature search was conducted, including clinical trials comparing BL/BLI combinations with standard antibiotic therapy or placebo. Primary outcomes included clinical cure rates (CCR), microbiological eradication, mortality, adverse events, and survival rates. The risk of bias was assessed using the Revised Tool for Risk of Bias in Randomized Trials (RoB 2.0). Meta-analysis was performed using Review Manager 5.4, and heterogeneity was quantified using the I² statistic. Results: Seventeen studies assessed CCR, demonstrating a significant advantage for BL/BLI combinations (Odds ratio (OR) 2.43 (95% CI 1.95–3.03) ). Thirteen studies reported microbiological eradication, favoring the intervention group (OR 2.45(1.42–4.24)). Twenty studies analyzed mortality, revealing a lower risk in the intervention group (OR 0.44(0.31–0.64)). Eight studies examined adverse events, indicating a lower incidence in the BL/BLI group (OR 0.600.40–0.91)). Three studies evaluated survival rates, showing a significant benefit with BL/BLI combinations (OR 2.02(1.10–3.71)). Conclusions: BL/BLI combinations in MDR-GNB infections significantly improved clinical cure rates, microbiological eradication, and survival. It also reduced mortality and adverse events, highlighting th superiority compared to standard therapy in MDR-GNB
}, number={4}, journal={Acta Biomedica Atenei Parmensis}, author={Ramadhan, Roy Novri and Zahra, Sophia and Rampengan, Derren DCH and Reviano, Aloysius Denzel Joshua and Yasin, Muhammad Nabhan and Jayanthi, Ruthvika and Raditya, Adrian Faza and Saputra, Ketut Wahyu Adi and Ega, Arya and Ariyanto, Melissa Valentina and Empitu, Maulana Antiyan and da Silva , Hendriketa and Kadariswantiningsih, Ika N.}, year={2026}, month={Aug.}, pages={18826} }