TY  - JOUR
AU  - Imzharov, Talgat A.
AU  - Balci, Melih
AU  - Zhakiev, Bazylbek
AU  - Kurmangaliev, Oleg
AU  - Sarkulov, Marat
AU  - Aslan, Yilmaz
AU  - Pavlov, Valentin
AU  - Lakman, Irina
AU  - Kelimberdiev, Mirsaid Saubetovich
TI  - Evaluation of the effectiveness of dioxydin metaphylaxis of nephrolithiasis in percutaneous nephrolithotripsy
PY  - %2026/%08/%07
Y2  - %2026/%08/%27
JF  - Acta Biomedica Atenei Parmensis
JA  - Acta Biomed
VL  - 97
IS  - 4
SE  - ORIGINAL RESEARCH ARTICLE - ORTHOPAEDICS AND SURGERY
DO  - 10.23750/abm.2026.19439
UR  - https://doi.org/10.23750/abm.2026.19439
SP  - 19439
AB  - Background and aim. Infectious complications and stone recurrence remain major challenges after percutaneous nephrolithotomy (PCNL) for large kidney stones. This study aimed to evaluate the effectiveness of adjunctive intracavitary 1% dioxidine administration for metaphylaxis of for reducing postoperative infectious complications and stone recurrence following PCNL.Methods. This prospective, randomized, single-blind controlled trial included 95 patients (aged 18–70 years) with kidney stones >2 cm undergoing PCNL. Patients were randomized 1:1 into control (standard systemic ceftriaxone therapy, n=48) and intervention groups (standard therapy plus intracavitary 10 ml 1% dioxidine intraoperatively and on postoperative days 1–2, n=47). Primary outcomes were bacteriuria and leukocyturia at 7 days and 3 months. Secondary outcomes included Clavien–Dindo complications, stone recurrence at 6 months (low-dose CT), laboratory parameters, and stone composition.Results. Intracavitary dioxidine significantly reduced bacteriuria at 7 days (10.6% vs 45.8%, p