TY  - JOUR
AU  - Bignami, Elena Giovanna
AU  - Russo, Michele
AU  - Cerdelli, Erika
AU  - Lanza, Roberto
AU  - Bellini, Valentina
TI  - A human-centered framework for Miss ICU: A multimodal, evidence-integrated artificial intelligence agent for clinical decision-making in intensive care
PY  - %2026/%08/%07
Y2  - %2026/%08/%27
JF  - Acta Biomedica Atenei Parmensis
JA  - Acta Biomed
VL  - 97
IS  - 4
SE  - FOCUS ON
DO  - 10.23750/abm.2026.18512
UR  - https://doi.org/10.23750/abm.2026.18512
SP  - 18512
AB  - Background and aim: The modern Intensive Care Unit (ICU) is a data-rich environment where an overwhelming volume of information can cause cognitive overload for clinicians. Artificial Intelligence (AI) is promising for predictive tasks, but adoption is limited by an implementation gap driven by poor data interoperability, model opacity, and inadequate integration into clinical workflows. This paper presents the "Miss ICU" framework, a novel AI agent designed as an intelligent partner for the critical care team. Its goal is to create an integrated, interpretable, and evidence-based system that augments, rather than replaces, clinical intelligence to improve patient outcomes.Methods: The framework uses a three-tiered architecture. A Data Harmonization Layer applies standards such as Health Level Seven/Fast Healthcare Interoperability Resources (HL7/FHIR) to build a unified patient data model. An Analytics Engine integrates machine learning for patient-state modeling, Natural Language Processing (NLP) for real-time evidence synthesis from medical literature, and Explainable AI (XAI) for transparency. A human-centered Presentation Layer provides an intuitive dashboard to display patient trajectory and risk.Results: The envisioned system offers clinicians a holistic view of patient status, including a stability curve to depict clinical trajectory. It aims to generate predictions (e.g., sepsis) with human-readable explanations of contributing factors and follows a multi-phase validation pathway ending in a pragmatic randomized controlled trial.Conclusions: Miss ICU offers a blueprint for next-generation clinical decision support, emphasizing interoperability, interpretability, and integration of patient data with medical evidence to reduce cognitive load, enable proactive care, and improve safety and quality in critical care. 
ER  -