Infrastructure determinants of urban-rural disparities in specialized cardiac care in Kazakhstan: A cross-sectional analytical study
Keywords:
cardiovascular diseases; healthcare accessibility; rural health; digitalization; cardiac rehabilitation; healthcare inequality; KazakhstanAbstract
Background and aim: Urban-rural disparities in cardiovascular healthcare accessibility remain an important public health problem in Kazakhstan despite ongoing healthcare reforms and expansion of specialized cardiac services. This study aimed to evaluate infrastructural determinants associated with accessibility and perceived quality of specialized cardiac care among urban and rural populations in the Almaty region of Kazakhstan.
Methods: A cross-sectional analytical study was conducted between September and December 2025 and included 350 patients with cardiovascular diseases and 152 healthcare professionals involved in cardiac care delivery. Data were collected using structured questionnaires assessing accessibility of specialized cardiac services, pharmaceutical supply, rehabilitation availability, digitalization, and perceived quality of care. Urban-rural differences were analyzed using chi-square and Mann–Whitney tests. Logistic and multivariable linear regression analyses were performed to identify determinants associated with patient dissatisfaction and professional-perceived quality of care.
Results: Rural patients reported significantly lower accessibility of high-technology medical care compared with urban residents (28.7% vs. 46.7%; p=0.019) and lower adequacy of pharmaceutical supply (31.7% vs. 51.1%; p=0.032). Insufficient drug supply was the strongest predictor of dissatisfaction with cardiac care (OR=2.31; 95% CI: 1.48–3.61; p<0.001). Inaccessibility of high-technology medical care (OR=1.89; 95% CI: 1.21-2.95; p=0.005) and rural residence (OR=1.62; 95% CI: 1.08–2.44; p=0.021) were also independently associated with dissatisfaction. Healthcare professionals identified digitalization level (β=0.40; p=0.017) and adequacy of material resources (β=0.35; p=0.002) as major determinants of perceived quality of care.
Conclusions: Substantial urban–rural disparities in specialized cardiac care persist in Kazakhstan and are primarily associated with infrastructural and organizational barriers. Improvement of pharmaceutical accessibility, digital integration, rehabilitation services, and continuity of care may represent key priorities for reducing regional inequalities in cardiovascular healthcare delivery.
References
1. Roth GA, Mensah GA, Johnson CO, et al. Global burden of cardiovascular diseases and risk factors, 1990–2019: update from the GBD 2019 study. J Am Coll Cardiol. 2020;76(25):2982-3021. doi: 10.1016/j.jacc.2020.11.010
2. Yusuf S, Joseph P, Rangarajan S, et al. Modifiable risk factors, cardiovascular disease, and mortality in 155 722 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study. Lancet. 2020;395(10226):795-808. doi: 10.1016/S0140-6736(19)32008-2
3. Aringazina A, Kuandikov T, Arkhipov V. Burden of the cardiovascular diseases in Central Asia. Cent Asian J Glob Health. 2018;7(1):321. doi:10.5195/cajgh.2018.321
4. Junusbekova G, Abdrakhmanov S, Kuttybaeva N, et al. Trends in cardiovascular disease mortality in Kazakhstan. Vasc Health Risk Manag. 2023;19:673-86. doi: 10.2147/VHRM.S430208
5. Mukasheva G, Abenova M, Shaltynov A, et al. Incidence and mortality of cardiovascular disease in the Republic of Kazakhstan: 2004-2017. Iran J Public Health. 2022;51(4):821-30. doi: 10.18502/ijph.v51i4.9243.
6. Mukasheva G, Akanov A, Davletov K, et al. Rural-urban health disparities for cardiovascular disease in the Republic of Kazakhstan. Open Access Maced J Med Sci. 2021;9(E):1324-31. doi: 10.3889/oamjms.2021.7598
7. Planey AM, Wardrip K, Perry M, et al. Structural factors and racial/ethnic inequities in travel times to acute care hospitals in the rural US South, 2007-2018. Milbank Q. 2023;101(3):922-74. doi: 10.1111/1468-0009.12641
8. Stansberry TT, Roberson PNE, Myers CR. US rural hospital care quality and the effects of hospital closures on the health status of rural vulnerable populations: an integrative literature review. Nurs Forum. 2023;2023:3928966. doi: 10.1155/2023/3928966
9. Alanazy ARM, Wark S, Fraser J, Nagle A. Factors impacting patient outcomes associated with use of emergency medical services operating in urban versus rural areas: a systematic review. Int J Environ Res Public Health. 2019;16(10):1728. doi: 10.3390/ijerph16101728
10. Taylor RS, Dalal HM, McDonagh STJ. The role of cardiac rehabilitation in improving cardiovascular outcomes. Nat Rev Cardiol. 2022;19(3):180-94. doi: 10.1038/s41569-021-00611-7
11. Zhakhina G, Gusmanov A, Sakko Y, et al. Heart failure burden in Kazakhstan among adults: data from Unified National Electronic Healthcare System 2014-19. Eur J Public Health. 2025;35(3):463-9. doi: 10.1093/eurpub/ckaf049
12. Semenova Y, Glushkova N, Pivina L, et al. Historical evolution of healthcare systems of post-soviet Russia, Belarus, Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, Uzbekistan, Armenia, and Azerbaijan: a scoping review. Heliyon. 2024;10(8):e29158. doi: 10.1016/j.heliyon.2024.e29158
13. Shynar K, Tokmurziyeva G, Yessirkepov M, et al. Cardiovascular diseases increased among the rural and urban population of North Kazakhstan during the COVID-19 pandemic. Rev Cardiovasc Med. 2024;25(3):100. doi: 10.31083/j.rcm2503100
14. Zhakhina G, Gusmanov A, Sakko Y, et al. Heart failure burden in Kazakhstan among adults: data from Unified National Electronic Healthcare System 2014-19. Eur J Public Health. 2025;35(3):463-9. doi: 10.1093/eurpub/ckaf049
15. Nakipov K, Yessirkepov M, Supiyev A, et al. Prevalence and risk factors of cardiovascular diseases among youth in Kazakhstan. Cent Asian J Med Hypotheses Ethics. 2025;6(3):151-63. doi: 10.47316/cajmhe.2025.6.3.07
16. von Elm E, Altman DG, Egger M, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61(4):344-9. doi: 10.1016/j.jclinepi.2007.11.008
17. Cu A, Meister S, Lefebvre B, Ridde V. Assessing healthcare access using the Levesque’s conceptual framework-A scoping review. Int J Equity Health. 2021;20(1):116. doi: 10.1186/s12939-021-01416-3
18. Voorhees J, Bailey S, Waterman H, Checkland K. Accessing primary care and the importance of human fit: a qualitative participatory case study. Br J Gen Pract. 2022;72(718):e342-e350. doi: 10.3399/BJGP.2021.0375
19. Berdeshova G, Musina A, Orakbay L, et al. Trend of cardiovascular diseases in the northern regions of the Republic of Kazakhstan at the outpatient level. Iran J Public Health. 2024;53(2):425-32. doi: 10.18502/ijph.v53i2.14927
20. Kassymkhan A, Ryskulova AG, Buribayeva Z, et al. Cardiovascular disease burden in rural Central Asia: a systematic review of epidemiological trends and mortality patterns. Epidemiologia (Basel). 2026;7(1):10. doi: 10.3390/epidemiologia7010010
21. Glushkova N, Turdaliyeva B, Kulzhanov M, et al. Examining disparities in cardiovascular disease prevention strategies and incidence rates between urban and rural populations: insights from Kazakhstan. Sci Rep 2023;13(1):20917. doi: 10.1038/s41598-023-47899-8
22. Fanaroff AC, Evans PT, Nathan AS. Rural-urban disparities in cardiovascular outcomes: getting to the root of the problem. J Am Coll Cardiol. 2022;79(3):280-2. doi: 10.1016/j.jacc.2021.11.016
23. Pierce JB, Ng SM, Stouffer JA, Williamson CA, Stouffer GA. Rural-urban disparities in cardiovascular disease in the US: what can be done to improve outcomes for rural Americans? Am J Cardiol. 2025;248:10-15. doi: 10.1016/j.amjcard.2025.03.033
24. Shurrab M, Ha ACT, Andrade JG, et al. Rural-urban disparities in the management and outcomes of atrial fibrillation in emergency departments in Canada. Circ Cardiovasc Qual Outcomes. 2025;18(11):e012366. doi: 10.1161/CIRCOUTCOMES.125.012366
25. Sritharan S, Wilsmore B, Wiggers J, et al. Rural-urban differences in outcomes of acute cardiac admissions in a large health service. JACC Adv. 2024;3(11):101328. doi: 10.1016/j.jacadv.2024.101328
26. Chow CK, Nguyen TN, Marschner S, et al. Availability and affordability of medicines and cardiovascular outcomes in 21 high-income, middle-income and low-income countries. BMJ Glob Health. 2020;5(11):e002640. doi: 10.1136/bmjgh-2020-002640
27. Husain MJ, Datta BK, Kostova D, et al. Access to cardiovascular disease and hypertension medicines in developing countries: an analysis of essential medicine lists, price, availability, and affordability. J Am Heart Assoc. 2020;9(9):e015302. doi: 10.1161/JAHA.119.015302
28. De Lathauwer ILJ, Nieuwenhuys WW, Hafkamp F, et al. Remote patient monitoring in heart failure: a comprehensive meta-analysis of effective programme components for hospitalization and mortality reduction. Eur J Heart Fail. 2025;27(9):1670-85. doi: 10.1002/ejhf.3568
29. Girerd N, Barbet V, Seronde MF, et al. Association of a remote monitoring programme with all-cause mortality and hospitalizations in patients with heart failure: national-scale real-world evidence from a 3-year propensity score analysis of the TELESAT-HF study. Eur J Heart Fail. 2025;27(9):1658-69. doi: 10.1002/ejhf.3563
30. Ploux S, Strik M, Ramirez FD, et al. Remote management of worsening heart failure to avoid hospitalization in a real-world setting. ESC Heart Fail. 2023;10(6):3637-45. doi: 10.1002/ehf2.14553
31. Gusmanov A, Zhakhina G, Yerdessov S, et al. Review of the research databases on population-based registries of Unified Electronic Healthcare System of Kazakhstan (UNEHS): possibilities and limitations for epidemiological research and real-world evidence. Int J Med Inform. 2023;170:104950. doi: 10.1016/j.ijmedinf.2022.104950
32. Kotseva K, De Bacquer D, Jennings C, et al. Cardiac rehabilitation in patients with coronary heart disease: provision, attendance, and outcomes: results from the INTERASPIRE survey from fourteen countries across six WHO regions. Glob Heart. 2025;20(1):75. doi:10.5334/gh.1458
33. Seron P, Oliveros MJ, Marzuca-Nassr GN, et al. Hybrid cardiac rehabilitation program in a low-resource setting: a randomized clinical trial. JAMA Netw Open. 2024;7(1):e2350301. doi: 10.1001/jamanetworkopen.2023.50301
34. Sergeyeva Y, Yermukhanova LS, Nurbakyt AN, et al. Phase II cardiac rehabilitation under compulsory insurance in Kazakhstan: a five-year cohort analysis of clinical and economic outcomes. J Clin Med. 2025;14(17):6317. doi: 10.3390/jcm14176317
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Akerke Kassymkhan, Zhanara Buribayeva, Nargiza Nassyrova , Symbat Аbzaliyeva , Erkin Mirrakhimov , Aivar Kenzhebayev, Kenzhebek Bizhanov, Zhanar Ibakova

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Transfer of Copyright and Permission to Reproduce Parts of Published Papers.
Authors retain the copyright for their published work. No formal permission will be required to reproduce parts (tables or illustrations) of published papers, provided the source is quoted appropriately and reproduction has no commercial intent. Reproductions with commercial intent will require written permission and payment of royalties.
